One of Australia's oldest wine regions, best known for Riesling wines. It lies in the Mid North of South Australia, approximately 120 km north of Adelaide.

The most important white variety is Riesling, with the Clare Valley regarded as its Australian home. Principal red varieties are Cabernet Sauvignon and Shiraz. They make a range of styles of varietal wines, reflecting different approaches to winemaking as well as the influences of the various sub-regions and micro-climates in the valleys. Many other lesser varieties are also grown, including Chardonnay, Semillon, Sauvignon Blanc, Pinot Noir, Tempranillo and Grenache. The Clare Valley region contributes around 2% of the Australian national grape crush, but wins over 7% of all medals awarded for Australian wine.