An American actress, best known for her current lead role on Showtime's television series Weeds portraying Nancy Botwin, for which she has received several nominations and the Golden Globe Award for Best Actress in 2006. She has appeared in films and series such as RED, Fried Green Tomatoes, Boys on the Side, The West Wing, Angels in America, for which she received a Golden Globe and an Emmy Award for Best Supporting Actress. She is also the recipient of the 2001 Tony Award for Best Actress for the Broadway play Proof.