She has appeared in a number of films with roles of various sizes, including the 1990s films American Beauty, The Object of My Affection, Big Night, The Impostors, Drop Dead Gorgeous, The Ice Storm, Primary Colors, 10 Things I Hate about You, and Private Parts, and the 2000s films Nurse Betty, The Hours, The Chumscrubber, How to Deal, Winter Solstice and a considerable role in the animated movie, Finding Nemo, voicing Peach, the starfish. In 1999, she was cast in the role of presidential press secretary C.J. Cregg on the television drama The West Wing, for which she eventually won four Emmy Awards..